Enzymology and Metabolism Journal


  • Research article - Lifesciences Published: Oct 07, 2016

    Endosomal Accumulation of Lipids in U18666a- Induced NPC Leads to Hyperphosphorylation of GFAP and Vimentin in Culture of Astrocytes

    Niemann-Pick type C disease (NPC) is characterized as a neurodegenerative disease caused by changes in lipid metabolism, particularly of cholesterol. Cholesterol levels are highly regulated among neurons and glia that changes in lipid metabolism, especially of cholesterol, lead to an imbalance causing NPC [1,2]. Lipoproteins and cholesterol in the central…

    -Daniela C. Santos, Carolina G. Fernandes, Pierozan P, Regina P. Pureur and Janice C. Coelho

  • Research article - Lifesciences Published: May 31, 2016

    Alterations of Cholesterol Metabolism in Inflammation-Induced Atherogenesis

    Vascular inflammation is central to the pathogenesis of the atherosclerotic lesion. In the setting of hypercholesterolemia, vascular inflammation accelerates the accumulation of cholesterol within arterial smooth muscle cells, macrophages, and other immune cells. In disorders such as obesity, diabetes, and thrombosis, a myriad of interactions between sterol metabolites and inflammatory…

    -David P. Hajjar and Katherine A. Hajjar

  • Research article - Lifesciences Published: Mar 09, 2016

    Antioxidant Activity of Natural Plant Extracts from the Perspective of their Effects against NO and its Oxidative Derivatives

    The antioxidant activity of natural substances is mainly attributed to their phenolic content. However, biological effects mediated by potentiating or inhibiting Nitric oxide (NO) and its derivatives in organism are diverse and controversial. In this short review we discussed three different modes of action of selected compounds through production or…

    -Janka Vaskova

  • Research article - Lifesciences Published: Sep 11, 2015

    Small "Crossovers" of Metabolic Processes but Potentially Great Factors of Health or Disease

    In biological systems, cellular metabolism is dependent on energy production. The main route of ATP synthesis in all eukaryotes is mitochondrial oxidative phosphorylation. Reactive oxygen species production occurs as a result of electron transfer reactions. Although mitochondria are responsible for the continuous production of reactive oxygen species, they are not…

    -Janka Vaskova

  • Research article - Lifesciences Published: Aug 14, 2015

    Kupffer Cell Metabolism and Function

    Kupffer cells are resident liver macrophages and play a critical role in maintaining liver functions. Under physiological conditions, they are the first innate immune cells and protect the liver from bacterial infections. Under pathological conditions, they are activated by different components and can differentiate into M1-like (classical) or M2-like (alternative)…

    -Nguyen-Lefebre AT and Anatolij Horuzsko